Fig 2: Association between YY1 gene expression and tumor survival prognosis in TCGA. By analyzing the YY1 expression of different cancers in the TCGA using the GEPIA2, we were able to determine the OS (a) and DFS (b). With remarkable results, a survival diagram and Kaplan-Meier curve were shown.

Fig 3: GSEA analysis of the effect of YY1 expression on cell signaling pathway in various cancers.

Fig 4: Phosphorylation of the YY1 protein in various tumors. We used UALCAN to compare the expression levels of YY1 phosphorylated proteins (NP_003394.1, S118, and S247 sites) among chosen normal tissue and primary tissue using the CPTAC. The phosphoprotein locations that yielded positive findings are depicted in the YY1 protein's schematic design (a). We provide the box plots for various malignancies such as breast cancer (b), ovarian cancer (c), colon cancer (d), clear cell RCC (e), UCEC (f), and LUAD (g).

Fig 5: The effect of YY1 mutation on gene expression and gene mutation on YY1 expression in various cancers. (a) The effect of YY1 mutation on gene expression in multiple myeloma and uterine cancer. (b) The effect of gene mutation on YY1 expression in cervix cancer, head and neck cancer, lung squamous cell carcinoma, sarcoma, and melanoma.